The American Society of Dermatopathology


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Interactive Case Study - January 2019

Erythematous Lesion on the Back

Douglas Rottmann, MD; Jennifer McNiff, MD


Question 1:

A 30-year-old man with a history of childhood leukemia presents with a sharply demarcated erythematous lesion on the back. The lesion has been present for five months. A biopsy is performed, showing the lesion below. Immunohistochemical staining reveals that the granular cells are negative for CD163 and S-100, but positive for CD68.
 
Click this image to view the virtual slide
 
 
Figure 1. A low-power, overall view (12x).

 
Figure 2. A low-power view (40x).

 
Figure 3. A medium-power view (100x).

 
Figure 4. A high-power view (200x).

 
Figure 5. A high-power view of the edge of the lesion (200x).

 
Figure 6. A higher-power view (400x).

 
Figure 7. CD163 stain of the tumor (200x).

 
Figure 8. S-100 stain of the tumor (200x).

 
Figure 9. CD68 stain of the tumor (200x).


 
What is the most likely diagnosis?