Interactive Case Study - February 2018

Question 1:

A 51-year-old female presented with an enlarging vulvar growth. Biopsy was performed and the histopathology is shown below (Figures 1-8).

Click the image to view the virtual slide 


Figure 1: 20x

 
Figure 2: 100x

 
Figure 3: 200x

 
Figure 4: 400x

 
Figure 5: S-100, 200x

 
Figure 6: Desmin, 100x

 
Figure 7: HMB45, 100x

 
Figure 8: Smooth Muscle Actin, 100x


 
Which of the following is the best diagnosis?

A.  Primary cutaneous perivascular epithelioid cell tumor

B.  Balloon/clear cell melanoma

C.  Clear cell benign fibrous histiocytoma

D.  Distinctive dermal clear cell mesenchymal neoplasm

E.  Cutaneous metastasis of renal cell carcinoma