Interactive Case Study - June 2023

Question 1:

A 53-year-old woman presents with small yellow papules with a ‘cobblestone appearance’ on the neck, axilla, and groin, as well as skin laxity in these areas. A punch biopsy was performed. Histopathologic findings are presented below. 

Click to view zoomable image


Figure 1: H&E 40X


Figure 2: H&E 100X


Figure 3: H&E 400X

Which of the following is the best diagnosis?

A.  Cutis laxa

B.  Late-onset focal dermal elastosis

C.  Pseudoxanthoma elasticum

D.  Pseudoxanthoma elasticum-like papillary dermal elastolysis

E.  White fibrous papulosis